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It must be utilized in combination with a low-calorie diet and frequent exercise in order to be effective. Using two separate drugs to lose weight can be very effective you will find combinations while watching FDA now awaiting approval. When dealing with weight loss and the people that go through it you need to err to the side of caution and permit the FDA do its job and demand some research be done so your public is aware of the side effects and dangers of the medications before we drive them. Keep in mind that drug companies come in business to generate money and that they would say anything to keep people on their medications. Researchers discovered that participants using this drug for the year, dropped a few pounds within four weeks and have kept the weight off through the 56 weeks from the study. Contrave can be a combination in the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs that are made up of many active ingredient, which can make them more effective and safer. Combo-pilling will be the newest fad or also the newest to come under scrutiny and therefore it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular may be the fact that by right now there are not any long term prescription weightloss pills that have been approved by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be approved by the FDA. Seizures really are a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug may also raise hypertension and heartbeat, and shouldn't be used in people who have a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise hypertension and pulse rate and must 't be used in patients with uncontrolled high hypertension, and also by you are not heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients using a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients towards the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking. An independent report published by Gant Daily in April also stated that naltrexone also works for kleptomaniacs and gambling addicts, as well. Citing research through the University of Minnesota School of Medicine, Gant Daily reported how the drug conditions kleptomaniacs and chronic gamblers in the same manner with alcohol and opioid addicts'by blocking the results of endorphins, that the brain releases when experiencing craving or compulsions.